產(chǎn)品編號(hào)：Y3705

英文名稱：Chelerythrine chloride　

CAS號(hào)：34316-15-9
分析標(biāo)準(zhǔn)品,>98%  
分子式 C21H18ClNO4 分子量383.83  

基本信息:

熔點(diǎn)   195-205°C
描述  
別名   白屈菜赤堿;白屈菜季銨堿;1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
生化機(jī)理  
Chelerythrine is potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Chelerythrine has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC50 = 1.5 μM) or Bad proteins and stimulates apoptosis.  
應(yīng)用   對(duì)某些真菌、細(xì)菌和病毒有抑制作用，但對(duì)神經(jīng)、心臟等有毒害，可引起麻痹、心臟抑制，甚至導(dǎo)致死亡。